ABSTRACT
Introduction: Albumin is the most abundant protein in serum and serves as a major transporter for many molecules. In maintaining homeostasis, albumin acts as a potential scavenger, antioxidant, and immunomodulator. As a transporter as well as an immunomodulator, the role of albumin and its correlation with anti-SARS-CoV-2 antibodies has not been widely studied. This study aims to measure the levels of albumin and IgG anti-SARS-CoV-2 N and S1 RBD proteins and determine whether there is a correlation between the two items. Materials and Methods: We conducted a cross-sectional study on 69 healthy adults aged 20–45 years who were fully vaccinated with SinoVac and then assessed the albumin and human IgG protein levels of SARS-CoV-2 N and S1 RBD proteins one month after the second dose using an ELISA method. Result: The average albumin level was 91.401 ng/mL and IgG was 11.419 Units/mL. Statistical calculations using the Spearman's rho correlation test got a significance value of 0.001 (p < 0.05) and the coefficient of correlation (r) value is 0.407, which means that there is a significant correlation between albumin and IgG anti-SARS-CoV-2 in people who were fully vaccinated with SinoVac, with a moderate coefficient of correlation. Conclusion: One of the immunomodulatory effects of albumin is to increase the expression of the pro-inflammatory gene, TNF-α, through the Toll-like receptor (TLR)-4 and NF-κB pathways. The presence of the TNF superfamily plays a role in the development, maturation, activation, and differentiation of B cells, which in turn produce a sufficient proportion of immunoglobulins. © 2023 UPM Press. All rights reserved.